The city of New York, New York, currently has 31 active clinical trials seeking participants for Depression research studies.
Feasibility and Acceptability of a Novel Cognitive Behavioral Skills Mobile App for Pregnant and Postpartum Individuals
Recruiting
This study aims to assess the feasibility and acceptability of the Maya Perinatal Cognitive Behavioral Skills App, a novel app for pregnant and postpartum individuals experiencing difficulties with mood, anxiety, or stress. Participants will complete the 12-module app to learn evidence-based strategies previously shown to help manage mood and anxiety. Assessments will include app feedback questionnaires, feedback interviews, a daily symptom tracker, and symptom measures. The study investigators... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
06/18/2025
Locations: Weill Cornell Medical College, New York, New York
Conditions: Perinatal Anxiety, Perinatal Depression
Mobile CBT for Middle Aged and Older Adults
Recruiting
This study aims to assess a mobile iPhone app called MAYA for use in middle-aged and older adults with anxiety or mood disorders. The MAYA app is designed to teach coping skills for anxiety and depression that are drawn from cognitive behavioral therapy. Participants will be asked to use the app for at least two days a week, 20 minutes on each day, for six weeks. Participants will have weekly check-ins as well as longer assessments at the beginning of the study, week 3, week 6 (end of treatment)... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
06/18/2025
Locations: Weill Cornell Medicine, New York, New York
Conditions: Anxiety Disorders and Symptoms, Depressive Symptoms, Depression
REstoring Mental Health Through COmmUnity-based Psychological Services in New York City
Recruiting
The goal is to improve mental health. The study will evaluate the impact of community-based mental health services. Successful completion of this study will contribute to the National Institute of Mental Health Strategic Plan employing implementation science to maximize the public health impact of research for effectiveness and reach of mental health services in the United States.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/17/2025
Locations: New School, New York, New York
Conditions: Depression, Anxiety, Psychological Distress, PTSD
Study of ABX-002 for the Adjunctive Treatment of Depressive Episodes Associated With Bipolar Disorder in Adults
Recruiting
The goal of this clinical trial is to learn if ABX-002 added to participants' existing treatment(s) shows effects on brain chemistry that may correlate with antidepressive effects. This is a single treatment arm, open-label, Phase 2 study of ABX-002 in 30 adults with bipolar depression. Five healthy volunteer participants will also be enrolled and receive no drug treatment, undergoing 2 imaging sessions to confirm instrument and test - retest method reliability control. For bipolar disorder pa... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
06/17/2025
Locations: Autobahn Site #202, New York, New York
Conditions: Bipolar Disorder Depression
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Recruiting
Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/12/2025
Locations: Hapworth Research Inc., New York, New York +1 locations
Conditions: Treatment Resistant Depression
Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD
Recruiting
Efficacy, Safety, and Tolerability of two administrations of COMP360 in participants with treatment-resistant depression (TRD)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/11/2025
Locations: Fieve Clinical Research, Inc, New York, New York +1 locations
Conditions: Treatment Resistant Depression
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
Recruiting
The goal of this clinical trial is to evaluate the effectiveness and safety of bilateral stimulation of the subcallosal cingulate white matter (SCCwm) using Deep Brain Stimulation (DBS) as an adjunctive treatment of non-psychotic unipolar Major Depressive Disorder (MDD) in adults.
Gender:
ALL
Ages:
Between 22 years and 70 years
Trial Updated:
06/03/2025
Locations: Mount Sinai Hospital, New York, New York
Conditions: Treatment Resistant Depression
ROSE in Sunset Park
Recruiting
The purpose of this study is to learn more about pregnant women's' experience with Reach Out, Stay Strong, Essentials for mothers of newborns (ROSE) and to evaluate the effectiveness of the ROSE program in preventing and reducing post-partum depressive symptoms, decreasing stress, and increasing social support among pregnant women.
Gender:
FEMALE
Ages:
Between 18 years and 100 years
Trial Updated:
05/27/2025
Locations: NYU Langone Health, New York, New York
Conditions: Post Partum Depression
A Digital Intervention for Post-Stroke Depression and Executive Dysfunction
Recruiting
Individuals with stroke commonly experience both depression and cognitive difficulties. The goal of this study is to evaluate the efficacy of a treatment that combines a digital therapeutic (an iPad-based cognitive training program) with learning cognitive strategies. The hypotheses are that this treatment will improve cognitive skills, depression symptoms, daily function, and brain connectivity. In the short-term, the findings will inform the efficacy of the intervention and in the long-term, m... Read More
Gender:
ALL
Ages:
Between 50 years and 79 years
Trial Updated:
05/23/2025
Locations: Weill Cornell Medical Center, New York, New York
Conditions: Executive Dysfunction, Depression, Stroke
Sequential Multiple Assignment Randomized Trial for Bipolar Depression
Recruiting
This is a sequential multiple assignment randomized trial for adults (ages \> 18) with a bipolar disorder type 1 diagnosis currently experiencing a depressive episode. It is a randomized pragmatic trial that will compare four commonly prescribed treatments for bipolar depression, which includes three FDA-approved medications (Cariprazine, Quetiapine and Lurasidone) and one antipsychotic/antidepressant combination (Aripiprazole/Escitalopram).
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/21/2025
Locations: New York University Grossman School of Medicine NYU, New York, New York +1 locations
Conditions: Bipolar I Disorder, Depression
Prevention of Psychological Health Problems Via Integrated Operational Support
Recruiting
Sub-clinical behavioral health services in the military are performed by BH technicians, who receive minimal training. Due to this, embedding more technicians in military units is unlikely to benefit service members. Giving technicians training in, and access to, evidence-based interventions (EBI) could make their work more effective. The proposed study is a training trial examining the efficacy of the full integrated operational support (IOS) toolkit (evidence-based interventions for behavioral... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/12/2025
Locations: New York University, New York, New York
Conditions: Depression, Anxiety, Grief, Leadership, Dissatisfaction
Personalized Mobile Cognitive Behavioral Therapy Application
Recruiting
This study aims to compare the effectiveness of a standard mobile iPhone cognitive behavioral therapy program to a personalized mobile iPhone cognitive behavioral therapy program that introduces new skills over a shorter period of time. Participants will use the Maya app for two days per week, at least 20 minutes per day, for six weeks. Assessments will include a weekly check in with a member of the research team, questionnaires, and optional magnetic resonance imaging (MRI) and electroencephalo... Read More
Gender:
ALL
Ages:
Between 18 years and 25 years
Trial Updated:
04/28/2025
Locations: Weill Cornell Medical College, New York, New York
Conditions: Anxiety Disorders and Symptoms, Depression, Bipolar Disorder, Symptoms