The city of New York, New York, currently has 32 active clinical trials seeking participants for Depression research studies.
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
Recruiting
The goal of this clinical trial is to evaluate the effectiveness and safety of bilateral stimulation of the subcallosal cingulate white matter (SCCwm) using Deep Brain Stimulation (DBS) as an adjunctive treatment of non-psychotic unipolar Major Depressive Disorder (MDD) in adults.
Gender:
ALL
Ages:
Between 22 years and 70 years
Trial Updated:
04/21/2025
Locations: Mount Sinai Hospital, New York, New York
Conditions: Treatment Resistant Depression
Mindfulness-Based fMRI Neurofeedback for Depression
Recruiting
In the United States, adolescents experience alarmingly high rates of major depression, and gold-standard treatments are only effective for approximately half of patients. Rumination may be a promising treatment target, as it is well-characterized at the neural level and contributes to depression onset, maintenance, and recurrence as well as predicts treatment non-response. Accordingly, the proposed research will investigate whether an innovative mindfulness-based real-time functional magnetic r... Read More
Gender:
ALL
Ages:
Between 13 years and 18 years
Trial Updated:
04/21/2025
Locations: Columbia University Irving Medical Center, New York, New York
Conditions: Depression in Adolescence, Rumination
Mobile Cognitive Behavioral Therapy for Stroke
Recruiting
This study aims to assess the feasibility and acceptability of "MAYA", a mobile cognitive behavioral therapy app for anxiety and mood disorders, in adults who have had a stroke.
Gender:
ALL
Ages:
Between 40 years and 79 years
Trial Updated:
04/21/2025
Locations: Weill Cornell Medicine, New York, New York
Conditions: Anxiety, Stroke, Depression
Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality
Recruiting
The investigators hypothesized that during the 9-week course of Engage \& Connect treatment there will be an increase in brain functions of the Positive Valence System which in turn will lead to reduction in suicidality.
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
04/21/2025
Locations: Weill Cornell Medicine, New York, New York
Conditions: Depression, Suicidal Ideation, Major Depressive Disorder, Depressive Disorder
RE104 Safety and Efficacy Study in Postpartum Depression
Recruiting
The purpose of this study is to determine if treatment with a single dose of RE104 for Injection reduces depressive symptoms in participants with moderate-to-severe postpartum depression (PPD) as compared to active-placebo.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
04/18/2025
Locations: Reunion Investigational Site, New York, New York +1 locations
Conditions: Postpartum Depression
Maintenance rTMS for Depression (Maitr-De)
Recruiting
Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising intervention for treatment-resistant depression (TRD), yet substantial uncertainties persist regarding its efficacy as a maintenance treatment. This prospective study seeks to investigate the efficacy of maintenance rTMS in individuals with TRD who have previously responded to an acute course of rTMS. In the R61 phase of the study, we will recruit 75 participants across three study sites, the University of California... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
04/14/2025
Locations: Weill Cornell Medicine, New York, New York
Conditions: Major Depressive Disorder, Treatment Resistant Depression
Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD
Recruiting
Efficacy, Safety, and Tolerability of two administrations of COMP360 in participants with treatment-resistant depression (TRD)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: Fieve Clinical Research, Inc, New York, New York +1 locations
Conditions: Treatment Resistant Depression
Study of ABX-002 for the Adjunctive Treatment of Depressive Episodes Associated With Bipolar Depression in Adults
Recruiting
The goal of this clinical trial is to learn if ABX-002 added to participants' existing treatment shows effects on brain chemistry that may relate to anti depressive effects This is a single treatment arm, open-label, Phase 2 study of ABX-002 in 30 adults with bipolar disorder and 5 healthy volunteers. Healthy volunteer participants will receive no drug treatment and will undergo 2 imaging sessions to confirm instrument and test - retest method reliability control. For bipolar disorder participa... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/25/2025
Locations: Autobahn Site #202, New York, New York
Conditions: Bipolar Disorder Depression
Virtual Neuro-Navigation System for Personalized Community Based TMS
Recruiting
Phase I study of a virtual neuro-navigation package with built-in support for identifying specific "surface-based" targets to optimze TMS treatment.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
03/24/2025
Locations: Columbia Docs, New York, New York
Conditions: Treatment Resistant Depression
Accelerated TMS for Depression and OCD
Recruiting
Repetitive transcranial magnetic stimulation (rTMS) is a FDA-approved treatment for depression and Obsessive Compulsive Disorder (OCD). The goal of the study is to learn how to optimize the treatment to improve symptoms of depression and OCD. This research project will test a new accelerated 5-day accelerated rTMS protocol for treating symptoms of depression and OCD. A second goal of this study is to identify biomarkers of depression and OCD in the brain using functional magnetic resonance imag... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/17/2025
Locations: Weill Cornell Medicine, New York, New York
Conditions: Depression, OCD
Biomarker-guided rTMS for Treatment Resistant Depression
Recruiting
Repetitive transcranial magnetic stimulation (rTMS) is a treatment for depression. The investigators are continuing to learn how to optimize outcomes from rTMS treatment. The purpose of this research project is to use brain network connectivity patterns as measured by resting state functional magnetic resonance imaging (fMRI) to confirm a way to optimize the use of rTMS to treat depression. In addition, the study aims to gain a better understanding of how rTMS influences brain networks.
Gender:
ALL
Ages:
Between 22 years and 65 years
Trial Updated:
03/17/2025
Locations: Weill Cornell Medicine, New York, New York
Conditions: Treatment Resistant Depression, Major Depressive Disorder
Living Healthy for Moms RCT
Recruiting
LHMoms is a novel integrated care intervention that focuses intensively on care continuity and community-to-healthcare linkages for postpartum birthing individuals. The intervention starts prior to discharge in the delivery hospitalization and extends to six months post-partum, thus covering critical windows to prevent long-term physical and mental health sequelae.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/11/2025
Locations: NewYork-Presbyterian Allen Hospital, New York, New York +1 locations
Conditions: Postpartum Depression (PPD), Cardiac Event